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Top Venture Capital Firms & Investors in the United States in 2025

Browse our list of American investors, including VC firms, angels, accelerators, and more. From seed to growth funding, discover the best investors in USA across a wide range of sectors.

Last update: September 18, 2025

List author: Lucas Roquilly

Shortlist investors, submit pitch decks, and get replies

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2,606 investors 

A Startup Founder’s Guide to United States Investors

Quick Facts About U.S. Startup Investment

The United States remains the undisputed global leader in venture capital activity, accounting for nearly half of all VC dollars deployed worldwide. Here's a snapshot of the 2024 landscape:

  • Total VC investment: $170 billion across 13,500+ deals (2023)
  • Active VC firms: Over 2,500, ranging from micro-funds to multibillion-dollar giants
  • Funding mix: Roughly 65% early-stage, 35% later-stage
  • Key government incentives: SBIR/STTR grants, Opportunity Zones, and R\&D tax credits
  • Concentration risk: Over 50% of all capital is funneled into California, New York, and Massachusetts

Top VC Cities in the U.S.

#1. San Francisco Bay Area (CA): The epicenter of venture capital, home to top firms and deep startup density in AI, SaaS, and biotech

#2. New York (NY): Fintech, media, and enterprise software dominance with strong East Coast capital base

#3. Boston (MA): Biotech and healthtech powerhouse anchored by MIT and Harvard

#4. Austin (TX): Rising tech ecosystem with strong momentum in B2B SaaS and cybersecurity

#5. Los Angeles (CA): Strength in climate tech, creator economy, and consumer apps

#6. Miami (FL): Increasing early-stage momentum in crypto, Web3, and fintech

Hottest Startup Industries in the USA

The U.S. startup scene is broad, but these sectors continue to attract outsized attention and capital. Explore the investor lists below for tailored deal flow:

Fintech: Still a top draw, particularly in embedded finance, lending infrastructure, and B2B payments. Explore Fintech Investors on OpenVC.

AI & Generative AI: Nearly $25 billion in 2023 funding; top use cases in dev tools, sales, and productivity. View AI Investors on OpenVC.

Healthtech: Massive growth in personalized medicine, diagnostics, and digital health platforms. Explore Healthtech Investors on OpenVC.

Climate Tech: VC dollars flowing into carbon removal, energy storage, and sustainable agriculture. Find Climate Tech Investors on OpenVC.

SaaS: Always in favor—strong ecosystems in San Francisco, Boston, and New York. Explore SaaS Investors on OpenVC.

Largest VC Firms in the U.S.

These firms consistently lead deal volume and size across stages:

  1. Andreessen Horowitz (a16z)

  2. Sequoia Capital

  3. Lightspeed Venture Partners

  4. Accel

  5. Kleiner Perkins

  6. Founders Fund

  7. Bessemer Venture Partners

  8. General Catalyst

Top Angel Investors in the U.S.

A mix of individuals and syndicates consistently show up in early-stage deals:

  • Naval Ravikant (AngelList)

  • Cyan Banister

  • Elad Gil

  • Garry Tan

  • Sahil Bloom

  • Spearhead and OnDeck angel programs

United States Investment Trends

Despite economic headwinds, U.S. venture remains resilient with key shifts worth noting:

  • Generative AI surge: Dominated late 2023, with several $1B+ rounds and multi-sector adoption

  • Crossover funds pulled back: Growth-stage deal volume fell significantly from 2021 highs

  • Seed and pre-seed stabilized: More disciplined rounds, but active

  • Venture debt rising: Startups increasingly using debt to extend runway

Top Funded U.S. Startups (2023–2024)

  • OpenAI – Generative AI, $10B+ investment from Microsoft

  • Anthropic – Generative AI, $4B+ across multiple rounds

  • Stripe – Fintech, $6.5B Series I

  • Databricks – Data/AI Infrastructure, $10B Series J

  • Ginkgo Bioworks – Synthetic Biology, $250M private placement

Useful Resources for American Startup Founders

America’s Seed Fund – Federal startup resource portal including SBIR/STTR programs

Small Business Administration (SBA) – Loan programs and startup counseling

OpenVC – Investor database and tools for finding the right investors/securing your raise.

Y Combinator Startup Library – Comprehensive tactical guidance for early-stage teams

Frequently Asked Questions

OpenVC is a free fundraising platform where startup founders can search verified investors,  submit their pitch decks, and manage their entire raise. Users can search 20,000+ verified investors, shortlist the right ones, and submit your pitch deck directly. Our CRM, deck analytics, and warm intro tools help you run a smarter, more organized raise.

Founders raise with OpenVC because it is designed to cut through the noise and get founders in front of the right investors, fast. With built-in tools for CRM, analytics, and warm intros, it helps you stay organized and improve your chances of getting a reply.

OpenVC is for early-stage startup founders who want to raise capital efficiently. Find investors from dozens of industries including SaaS, AI, fintech, biotech, and more. Whether you’re pre-seed, seed, or Series A, OpenVC helps you find and pitch aligned investors without paying intro fees, aimlessly cold-emailing, or scraping databases.

Yes, OpenVC is completely free to use. You can search investors, submit your pitch deck, track engagement, and manage your raise—all without paying a cent. Premium features are available, but the core platform is free and always will be.

You create a free OpenVC account, build your investor shortlist, and submit your pitch deck directly through the platform. Investors receive a unique link to view your deck, and you get analytics on who opens it and how long they spend on it. No cold emails, no guesswork. For more info, check out our complete guide to fundraising on OpenVC.

Absolutely, OpenVC is designed for early-stage fundraising. You’ll find thousands of angel investors, pre-seed VCs, accelerators, incubators, and family offices who are actively backing startups across sectors and geographies. Use OpenVC’s filters to narrow your search and find the right investors for your startup.

Some examples of startups that successfully secured funding through OpenVC include Mobly (2.5M seed), Paxum ($1.2M seed), and Laennec AI ($400k pre-seed). OpenVC startups have gone on to raise more than $1 billion from top venture capital firms like YC, Sequoia, Google Ventures, and M12.

OpenVC was created by Stephane Nasser and Lucas Roquilly—two founders building tools to make startup fundraising more transparent and accessible. We launched OpenVC to help founders find investors, get replies, and raise smarter. The platform is bootstrapped, community-driven, and built with a lot of heart.

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